Strecker synthesis

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Strecker synthesis

  Strecker synthesis 

Strecker synthesis

The strecker synthesis is a prepration of a-aminonitriles,  wich are versatile intermediates from the synthesis of amino acids via hydrolysis of the nitrile 

Mechanism of the strecker synthesis

The reaction us promoted by acid,  and HCN must be supplied generated in situ from cynide salts -in the latter case,  one equivalent of acid is consumed in the reaction. 

Strecker synthesis

The first step is probably the condensation of ammonia with the aldehyde to form an imine.

The cyanide adds as a nucleophile to the amine carbon,  generating the a - amino nitrile 


This product may optionally be hydrolysed to the corresponding A-ha amino-acid.
Strecker synthesis


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