Reformatsky Reaction
The formation of Ester-Stabilized organozic reagents and their and there addition to carbonyl compounds
Mechanism of the Reformatsky Reaction
Organozinz compounds are prepared from a-halogenesters in tge same manner as Grignard Reagents. This reaction is possible due to the stability of esters against organozincs. Due to the very low basicity of zinc enolates, there is hardly any competition from proton transfer, and the scope of carbonyl addition partners is quit broad. In presence of ketones or aldehydes , the organozinc compounds react as the nucleophilic partner in an addition to give B-hydroxy esters
An ester-stablized organozinc reagent
Compared to organolithiums and organomagnesium halides (Grignard reagents) , the organozinc halide reagents used in the Reformatsky reaction are relatively stable, and many are available commercially.
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