Reformatsky Reaction

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Reformatsky Reaction

 Reformatsky Reaction 

Reformatsky Reaction

The formation of Ester-Stabilized organozic reagents and their and there addition to carbonyl compounds

Mechanism of the Reformatsky Reaction 

Organozinz compounds are prepared from a-halogenesters in tge same manner as Grignard Reagents. This reaction is possible due to the stability of esters against organozincs. Due to the very low basicity of zinc enolates,  there is hardly any competition from proton transfer,  and the scope of carbonyl addition partners is quit broad.  In presence of ketones or aldehydes , the organozinc compounds react as the nucleophilic partner in an addition to give B-hydroxy esters 

Reformatsky Reaction

An ester-stablized organozinc reagent

Compared to organolithiums and organomagnesium halides (Grignard reagents) , the organozinc halide reagents used in the Reformatsky reaction are relatively stable,  and many are available commercially.

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