Combinatorial chemistry

 What is combinatorial chemistry

Combinatorial chemistry is a laboratory technique in which millions of molecular constructions can be synthesized and tested for biological activity. It hs generated massive number of targeted molecules for testing and the developing techniques of high throughput screening has automated the screening process so large numbers of biological assays can be done.  All this together has reduced the discovery -to-market time from what used to be 10-14 years to 5-8 years

       In a traditional organic synthesis lab,  the chemist does the standard reaction A+B----->C. But whith combinatorial chemistry A is a mixture of perhaps 5 components and B is a mixture of 10 so instead of getting one product the chemist now gets 50. This library allows for the input of single generic structure, like benzodiazepine, whit the output giving a complete range of benzodiazepine derivatives all in specified molicular weight range which differ in the composition of the different R groups (figure1). The output of wich as seen in fig 2,gives different derivatives of benzodiazepine.